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From Dr. Joseph Mercola
Since COVID-19 first entered the scene, change of concepts has mainly been outlawed. By sharing my views and people from varied specialists all through the pandemic on COVID remedies and the experimental COVID jabs, I turned a predominant goal of the White Home, the political institution and the worldwide cabal.
Propaganda and pervasive censorship have been deployed to grab management over each a part of your life, together with your well being, funds and meals provide. The key media are key gamers and have been instrumental in creating and fueling worry.
I’m republishing this text in its authentic kind in an effort to see how the development unfolded.
Initially printed: April 25, 2020
Molecular hydrogen (H2 gasoline) has highly effective antioxidant and anti inflammatory results,1 as defined on this video by Tyler W. LeBaron, founding father of the science-based nonprofit Molecular Hydrogen Institute.
In his video, LeBaron evaluations the pathophysiology of COVID-19 and explains why H2 is being clinically investigated by discussing the proposed mechanisms of how molecular hydrogen may ameliorate illness.
In actual fact, a number of Chinese language investigators are utilizing H2 remedy in COVID-19 sufferers,2,3 and preliminary outcomes4,5 are encouraging sufficient that Dr. Zhong Nanshan, the epidemiologist who found the SARS virus (SARS-CoV-1) in 2003, is now recommending H2 remedy for COVID-19.6
Whereas extra analysis is required to substantiate advantages and helpful outcomes in COVID-19 circumstances, the most recent COVID-19 remedy information7 by the Chinese language Nationwide Well being Fee consists of hydrogen inhalation.
LeBaron features a video clip of Chinese language sufferers given a hydrogen-oxygen inhaler combine, who say it eradicated chest ache and cough, and allowed for deeper respiration with out discomfort. That mentioned, LeBaron notes:
“There’s nonetheless no clinically printed proof that H2 will actually profit COVID-19 and this info is solely for academic functions. It doesn’t represent medical proof, and isn’t meant to interchange the steering out of your well being care practitioner.”
Pathophysiology of COVID-19
As defined by LeBaron, the SARS-CoV-2 virus answerable for COVID-19 enters the lungs, the place it assaults the sort 2 pneumocytes,8 alveolar cells answerable for the secretion of surfactants that scale back the floor rigidity of fluids in your lungs and are thus vital for elasticity.
The SARS-CoV-2 virus makes use of a spiked protein to anchor itself to the ACE-2 receptor9 of the cell. That is the way it good points entry and releases its positive-sense single-strand RNA into the cell. By inserting its RNA, the virus primarily hijacks the cell, because it triggers viral replication to happen contained in the cell.
In response, macrophages (white blood cells) are activated to fight the an infection, and so they in flip launch a wide range of cytokines, together with interleukin-6 (Il-6), IL-1 and TNF-alpha, into your blood plasma. As soon as the cytokines enter your plasma, neutrophils are recruited, thus growing vasodilation (growth of your blood vessels) and capillary permeability.
Contained in the cell, reactive oxygen species (ROS) are additionally created in an effort to kill the contaminated cell and forestall viral replication. That is an important a part of your physique’s protection system. Nonetheless, as the method progresses you find yourself with growing quantities of ROS and irritation. Worse, because the virus continues to assault your sort 2 pneumocytes, your lungs can’t work accurately.
Because the floor rigidity of the fluids in your lungs is decreased, your alveoli can not keep the correct gasoline change, and your oxygen requirement goes up. Declining elasticity of the lungs additionally makes respiration tougher. Add in excessive quantities of ROS, and the entire alveoli finally ends up dying. That is a part of what’s inflicting the cough.
As irritation and vasodilation progresses, you possibly can find yourself with low blood stress, which is why you are feeling fatigued and weak. Decrease blood stress additionally causes low blood perfusion, which in flip means your cells is not going to get the oxygen and vitamins they want for optimum operate. It additionally impairs metabolic waste elimination. The low oxygen ranges (hypoxia) end in feeling in need of breath.
Except efficiently handled, this chain of occasions results in cell loss of life, multi-system organ failure (lungs, liver and kidneys), acute respiratory misery (ARD) and, finally, loss of life.
Stopping the Damaging Cycle
To avoid wasting the affected person, one thing must be achieved to cease this harmful cascade of occasions. How can we inhibit viral replication and increase immune system operate? As defined by LeBaron, many of the destruction happens by ROS and systemic irritation.
ROS are molecules that trigger oxidative harm. Nonetheless, they don’t seem to be all dangerous on a regular basis. Neutrophils that produce ROS additionally produce nitric oxide and superoxide, that are essential. Superoxide helps kill the pathogen, however you additionally don’t desire an excessive amount of of it, so it must be regulated.
Nitric oxide additionally must be regulated. Whereas it might inhibit viral replication and helps increase your immune system, you do not need an excessive amount of. As ranges of superoxide and nitric oxide rise, they begin forming peroxynitrites, that are extraordinarily damaging, which in flip kind hydroxyl radicals, essentially the most cytotoxic ROS.
Usually, when superoxide has achieved its job, it is transformed by superoxide dismutase into hydrogen peroxide, which in flip is transformed into water and oxygen.
This course of is regulated by a transcription issue known as Nrf2/keap1. When this transcription issue is activated, it goes into the cell’s nucleus, the place it binds with the antioxidant response component (ARE), which triggers your physique’s pure antioxidants similar to glutathione and catalase.
As famous by LeBaron, Nrf2 — which is concerned in section 2 cleansing — regulates greater than 200 protecting proteins and enzymes. The issue is that when ROS is overabundant and uncontrolled, the Nrf2 system is depleted and may not regulate the inflammatory course of.
Understanding Molecular Hydrogen
Molecular hydrogen or H2 has the flexibility to activate the Nrf2/keap1 pathway, thereby replenishing your endogenous antioxidants. In so doing, H2 helps regulate and keep homeostasis in the entire system, stopping the an infection from getting uncontrolled and inflicting cell loss of life.
Hydrogen may downregulate NOX and NOS enzymes, thus decreasing superoxide and nitric oxide manufacturing respectively. That is good, as when these two molecules are elevated an excessive amount of they immediately mix to create the pernicious peroxynitrite molecule. H2 additionally helps your mitochondrial operate. Importantly, H2 selectively reduces peroxynitrites and hydroxyl radicals.
This provides H2 a big benefit over different antioxidants similar to vitamin C, which act indiscriminately with superoxide and nitric oxide — each of which even have vital and helpful features. H2 doesn’t work together with both superoxide or nitric oxide. The one factor H2 can react with are essentially the most harmful ROS similar to peroxynitrites and hydroxyl radicals.10
Consequently, your superoxide and nitric oxide are left to carry out helpful features whereas the H2 eliminates essentially the most harmful byproducts of superoxide and nitric oxide, whereas concurrently growing your physique’s pure manufacturing of antioxidants and regulating the enzymes that produce superoxide and nitric oxide. To get a clearer image in your thoughts of how H2 steps in to interrupt the harmful chain, see LeBaron’s video.
H2 additionally steps in to forestall a cytokine storm from occurring. A cytokine storm happens when the upregulation of cytokines is bigger than your physique can deal with. Cytokines are regulated by transcription components, and ROS regulate these transcription components. Inflammatory transcription components, in flip, create extra irritation, which stimulate extra ROS manufacturing.
This can be a vicious cycle that leads to elevated cell loss of life, which results in multiorgan failure, which results in loss of life. H2 has been proven to manage these transcription components in a number of animal and human research, thus breaking the vicious cycle. That is what makes H2 so anti-inflammatory. As summarized by LeBaron on the finish of his video:
“Hydrogen gasoline, being a quite simple, small molecule, can assist to manage the redox standing of the cell by selectively lowering the very dangerous [ROS], assist to manage and enhance the Nrf2/keap1 pathway to take care of our physique’s redox homeostasis.
It additionally has regulatory results on irritation, to decrease persistent, dangerous systemic irritation by regulating the whole lot. Simply lowering or inhibiting it [referring to ROS] just isn’t need we wish to do. We want all of these items.
That is in our immune system. We do not simply wish to do away with it. Sure, it’s what’s killing us, however it is usually crucial to have, in order that we will get higher. So, that’s the … rationale for [using hydrogen gas] for COVID-19.”
Dosing and Availability
Though the precise medical research on COVID-19 are being performed with H2 inhalation, H2 dissolved in water has been proven to be simpler than inhalation in different animal illness fashions.11 Moreover, one other article12 means that the H2-infused nitric oxide-producing beverage from H2Bev known as HydroShot, must also be clinically investigated for its reported preliminary results.
Nonetheless, whereas there are numerous methods of getting H2, the only and most sensible supply system is molecular hydrogen tablets which are dissolved in water. They’re moveable and may be taken wherever, together with journey and on airways, and so they constantly present a excessive H2 focus. When utilizing the tablets it is vital to drink the water as quickly because the tablets are dissolved and the water continues to be “white,” because the H2 dissipates rapidly.
The molecular hydrogen tablets have the extra benefit of offering 80 mg of ionic elemental magnesium with every pill. Magnesium can function a pure calcium channel blocker to assist regulate excessive intracellular calcium ranges that may wreak havoc in your physique.
Additionally, absolutely the amount of H2 is much much less vital than pulsing or creating an acute elevation of H2 in your system over a brief interval. That acute elevation is what prompts the Nrf2 pathway. When publicity is steady, even when elevated, it has just about no impact.
Clearly, we’d like extra analysis to be higher capable of reply dosing questions, however within the interim, it appears customizing the dose to your private circumstances can be most applicable. So, when you’re in regular, non-stressful circumstances at house, not likely doing something very traumatic and never exercising a lot, perhaps taking H2 as soon as a day is enough.
Nonetheless, when you train so much, it’s possible you’ll wish to take it two to 3 occasions a day to assist scale back the oxidative stress out of your train. Ditto when you’re touring and exposing your self to free radical stress from ionizing radiation at 35,000 toes. In such a circumstance, it is perhaps applicable to take it each two hours whilst you’re within the air.
Contemplating their security, ease of use, and helpful results on immune operate and well being, molecular hydrogen tablets are a no brainer resolution for my part, and so they may very well be fairly useful for a lot of situations, together with COVID-19, which is why H2 is being clinically investigated.
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